Is dietary glycemic load associated with liver fibrosis in hepatitis C?

INTRODUCTION: Occidental diet and metabolic profile seems to increase hepatic fibrosis (HF) in patients with chronic hepatitis C virus (HCV) infection, but there is scarce information about the diet components and their role in this setting. OBJECTIVES: This study aims to evaluate the dietary intake, metabolic profile, presence of metabolic syndrome (MetS) and cardiovascular risk in patients with chronic HCV infection according to the presence of fibrosis. METHODS: Cross-sectional study which 58 patients with HCV infection without active antiviral therapy and non-cirrhotic were assessed. All patients were subjected to clinical, laboratorial and dietary evaluation, and classified according to the METAVIR score. Patients were divided as the presence of hepatic fibrosis. RESULTS: In this sample, fifty-five percent of patients were females, the average age was 51.6 ± 9.7 years, and 79.3% were carriers of HCV genotype 1. Patients with HF presented higher energy, and fat intake as well as higher glycemic load of meals in comparison to those without HF. Patients with HF presented higher systolic and diastolic arterial pressure and higher levels of insulin. CONCLUSIONS: In conclusion, patients with HF had higher total daily energy and total fat intakes, and worse metabolic profile, characterized by a higher insulin resistance and blood pressure.

Is dietary glycemic load associated with liver fibrosis in hepatitis C? / ¿Está asociada la carga glucémica en la dieta con la fibrosis hepática en la hepatitis C?

Introduction: Occidental diet and metabolic profile seems to increase hepatic fibrosis (HF) in patients with chronic hepatitis C virus (HCV) infection, but there is scarce information about the diet components and their role in this setting. Objectives: This study aims to evaluate the dietary intake, metabolic profile, presence of metabolic syndrome (MetS) and cardiovascular risk in patients with chronic HCV infection according to the presence of fibrosis. Methods: Cross-sectional study which 58 patients with HCV infection without active antiviral therapy and non-cirrhotic were assessed. All patients were subjected to clinical, laboratorial and dietary evaluation, and classified according to the METAVIR score. Patients were divided as the presence of hepatic fibrosis. Results: In this sample, fifty-five percent of patients were females, the average age was 51.6 ± 9.7 years, and 79.3% were carriers of HCV genotype 1. Patients with HF presented higher energy, and fat intake as well as higher glycemic load of meals in comparison to those without HF. Patients with HF presented higher systolic and diastolic arterial pressure and higher levels of insulin. Conclusions: In conclusion, patients with HF had higher total daily energy and total fat intakes, and worse metabolic profile, characterized by a higher insulin resistance and blood pressure (AU)

Introducción: en pacientes infectados crónicamente por el virus de la hepatitis C (VHC), la dieta occidental y el perfil metabólico parecen aumentar la fibrosis hepática (FH), sin embargo, existe poca información sobre los componentes de la dieta y su papel en este contexto. Objetivos: evaluar la ingesta dietética, el perfil metabólico, la presencia de síndrome metabólico (SAT) y el riesgo cardiovascular en pacientes con VHC crónico según la presencia de fibrosis. Métodos: estudio transversal en el que se evaluaron 58 pacientes con VHC sin terapia antiviral activa ni cirrótica. Todos los pacientes fueron sometidos a evaluación clínica, de laboratorio y dietética, y fueron clasificados según la puntuación METAVIR. Los pacientes se dividieron según la presencia de FH. Resultados: en esta muestra el 55% de los pacientes eran mujeres, con edad promedio de 51,6 +/- 9,7 anos, siendo el 79,3% portadores del genotipo 1 del VHC. Los alimentos de los pacientes con FH presentaron una mayor proporción de energía y grasa, así como mayor carga glucémica en comparación con las personas sin FH. Los pacientes con circunferencia de la cintura presentaron mayor presión arterial sistólica y diastólica y mayores niveles de insulina. Conclusión: en conclusión, los pacientes con FH presentaron un consumo mayor de energía y grasas diario total, y peor perfil metabólico, caracterizado por mayor resistencia a la insulina y presión arterial (AU)